Models of Contagious Bovine Pleuropneumonia: Evaluation of Two Novel Strains
نویسندگان
چکیده
The clinical course of infection following endobronchial inoculation of three strains of Mycoplasma mycoides subspecies mycoides small colony (MmmSC), the causative agent of Contagious Bovine Pleuropneumonia (CBPP), was compared in 15 mixed-breed Bos taurus steers. Two of these strains have not previously been investigated under experimental conditions. The cattle were inoculated endobronchially with MmmSC strain Gladysdale, Ondangwa or Shawawa and monitored for 42 days. Four of five Gladysdale-inoculated cattle developed acute clinical CBPP. Four of five Ondangwa and 3/5 Shawawa-inoculated cattle developed subacute to chronic CBPP without overt clinical signs but had characteristic pathological lesions. MmmSC was isolated from cattle both during the course of infection and at necropsy. Clinical signs and necropsy lesions were consistent within groups. Ondangwa and Shawawa strains of MmmSC may be useful for study of subacute and chronic CBPP, which is more common in natural infection than peracute CBPP. Use of recent strains will enhance study of CBPP host response, pathogen detection and vaccine development.
منابع مشابه
Pharmacodynamics of Antimicrobials against Mycoplasma mycoides mycoides Small Colony, the Causative Agent of Contagious Bovine Pleuropneumonia
BACKGROUND Mycoplasma mycoides subspecies mycoides Small Colony (MmmSC) is the causative agent of Contagious Bovine Pleuropneumonia (CBPP), a disease of substantial economic importance in sub-Saharan Africa. Failure of vaccination to curtail spread of this disease has led to calls for evaluation of the role of antimicrobials in CBPP control. Three major classes of antimicrobial are effective ag...
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